Refining diagnostic microRNA signatures by whole-miRNome kinetic analysis in acute myocardial infarction.

@article{Vogel2013RefiningDM,
  title={Refining diagnostic microRNA signatures by whole-miRNome kinetic analysis in acute myocardial infarction.},
  author={Britta Vogel and Andreas Keller and Karen S. Frese and Wanda Kloos and Elham Kayvanpour and Farbod Sedaghat-Hamedani and Sarah Hassel and Sabine Marquart and Markus Beier and Evangelos Giannitis and Stefan Hardt and Hugo A. Katus and Benjamin Meder},
  journal={Clinical chemistry},
  year={2013},
  volume={59 2},
  pages={410-8}
}
BACKGROUND Alterations in microRNA (miRNA) expression patterns in whole blood may be useful biomarkers of diverse cardiovascular disorders. We previously reported that miRNAs are significantly dysregulated in acute myocardial infarction (AMI) and applied machine-learning techniques to define miRNA subsets with high diagnostic power for AMI diagnosis. However, the kinetics of the time-dependent sensitivity of these novel miRNA biomarkers remained unknown. METHODS To characterize temporal… CONTINUE READING
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420–6

  • van Rooij J Cappuzzello C Greco S Arcelli D Di Vito L Voellenkle C, 42
  • 418 Clinical Chemistry 59:2
  • 2013

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