Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene.

@article{Blankenhorn2007RefinementOT,
  title={Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene.},
  author={Elizabeth P. Blankenhorn and Cheryl Descipio and Lucy Rodemich and Laura Cort and Jean H. Leif and Dale L. Greiner and John P. Mordes},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1103},
  pages={128-31}
}
Iddm4 is a dominant non-major histocompatibility complex (MHC) determinant of diabetes susceptibility in BBDR rats treated with poly I:C, plus depletion of regulatory T cells. In congenic MHC-identical normal WF rats, Iddm4(d) sensitively and specifically predicts induced diabetes. We report a new diabetes-susceptible subcongenic line that carries Iddm4 in a < 2.6 megabase interval. Candidate genes include the T cell receptor beta chain variable (TCRVbeta) family. We found that TCRVbeta4 in WF… CONTINUE READING

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