Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling.

@article{Miller2011RefinementOG,
  title={Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling.},
  author={Laurence J. Miller and Quan Chen and Polo H C Lam and Delia I. Pinon and Patrick M. Sexton and Ruben Abagyan and Maoqing Dong},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 18},
  pages={15895-907}
}
The glucagon-like peptide 1 (GLP1) receptor is an important drug target within the B family of G protein-coupled receptors. Its natural agonist ligand, GLP1, has incretin-like actions and the receptor is a recognized target for management of type 2 diabetes mellitus. Despite recent solution of the structure of the amino terminus of the GLP1 receptor and several close family members, the molecular basis for GLP1 binding to and activation of the intact receptor remains unclear. We previously… CONTINUE READING