Refinement of 1p36 Alterations Not Involving PRDM16 in Myeloid and Lymphoid Malignancies

  title={Refinement of 1p36 Alterations Not Involving PRDM16 in Myeloid and Lymphoid Malignancies},
  author={Francois P. Duhoux and Genevi{\`e}ve Ameye and Virginie Lambot and Christian Herens and Fr{\'e}d{\'e}ric Lambert and Sophie Raynaud and Iwona Wlodarska and Lucienne Michaux and Catherine Roche-Lestienne and Elise Labis and Sylvie Taviaux and Elise Chapiro and Florence Nguyen Khac and St{\'e}phanie Struski and Sophie Dobbelstein and Nicole Dastugue and Eric Lippert and Frank Speleman and Nadine Van Roy and An De Weer and Katrina Rack and Pascaline Talmant and Steven Richebourg and Francine Mugneret and Isabelle Tigaud and M J Mozziconacci and Sophy Laibe and Nathalie Nadal and Christine Terr{\'e} and J Libouton and Anabelle Decottignies and Miikka Vikkula and H{\'e}l{\`e}ne A Poirel},
  booktitle={PloS one},
Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus. In total, three subgroups were identified: balanced translocations (N = 27) and telomeric rearrangements (N = 15), both mainly observed in myeloid disorders; and unbalanced non-telomeric rearrangements (N = 39), mainly observed in lymphoid proliferations and frequently associated with a highly complex karyotype. The 1p36… CONTINUE READING
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