Refined model of the 10S conformation of smooth muscle myosin by cryo-electron microscopy 3D image reconstruction.

@article{Liu2003RefinedMO,
  title={Refined model of the 10S conformation of smooth muscle myosin by cryo-electron microscopy 3D image reconstruction.},
  author={Jun Liu and T Leighton Wendt and Dianne W. Taylor and Kenneth A Taylor},
  journal={Journal of molecular biology},
  year={2003},
  volume={329 5},
  pages={
          963-72
        }
}
  • Jun Liu, T Leighton Wendt, +1 author Kenneth A Taylor
  • Published in Journal of molecular biology 2003
  • Chemistry, Medicine
  • The actin-activated ATPase activity of smooth muscle myosin and heavy meromyosin (smHMM) is regulated by phosphorylation of the regulatory light chain (RLC). Complete regulation requires two intact myosin heads because single-headed myosin subfragments are always active. 2D crystalline arrays of the 10S form of intact myosin, which has a dephosphorylated RLC, were produced on a positively charged lipid monolayer and imaged in 3D at 2.0 nm resolution by cryo-electron microscopy of frozen… CONTINUE READING

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