Refined genetic mapping of the darier locus to a <1-cM region of chromosome 12q24.1, and construction of a complete, high-resolution P1 artificial chromosome/bacterial artificial chromosome contig of the critical region.

@article{Monk1998RefinedGM,
  title={Refined genetic mapping of the darier locus to a <1-cM region of chromosome 12q24.1, and construction of a complete, high-resolution P1 artificial chromosome/bacterial artificial chromosome contig of the critical region.},
  author={Sarah Monk and Anavaj Sakuntabhai and Shelly A Carter and Steven Bryce and R. B. Cox and Lesley Harrington and Elaine Levy and Victor L. Ruiz-P{\'e}rez and Eleni Z. Katsantoni and Ahmer Kodvawala and Colin S. Munro and Susan Burge and Marc Larr{\`e}gue and G{\'a}bor Nagy and Jonathan Laurence Rees and Mark Lathrop and Anthony P Monaco and T. Strachan and Alain Hovnanian},
  journal={American journal of human genetics},
  year={1998},
  volume={62 4},
  pages={890-903}
}
Darier disease (DD) (MIM 124200) is an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and by abnormal keratinization. We present linkage analysis showing, in four families, key recombination events that refine the location of the DD locus on chromosome 12q23-24.1 to a region of <1 cM. We have constructed a YAC/P1 artificial chromosome (PAC)/bacterial artificial chromosome (BAC)-based physical map that encompasses this refined DD region. The map… CONTINUE READING