Refined crystal structure of dogfish M4 apo-lactate dehydrogenase.

  title={Refined crystal structure of dogfish M4 apo-lactate dehydrogenase.},
  author={Celerino Abad-Zapatero and James P. Griffith and Joel L. Sussman and Michael G. Rossmann},
  journal={Journal of molecular biology},
  volume={198 3},
The crystal structure of M4 apo-lactate dehydrogenase from the spiny dogfish (Squalus acanthius) was initially refined by a constrained-restrained, and subsequently restrained, least-squares technique. The final structure contained 286 water molecules and two sulfate ions per subunit and gave an R-factor of 0.202 for difraction data between 8.0 and 2.0 A resolution. The upper limit for the co-ordinate accuracy of the atoms was estimated to be 0.25 A. The elements of secondary structure of the… CONTINUE READING