Reference region based modeling in DCE-MRI allows reliable therapy response monitoring despite drug induced systemic changes in a rat liver tumor model

Introduction: A persistent limitation in quantitative DCE-MRI is the difficulty of the simultaneous measurement of the arterial input function (AIF), and the CA concentration in the tumor tissue. The use of an AIF previously determined in a small population (population AIF (popAIF) model) or the concurrent measurement of CA uptake in a reference tissue… CONTINUE READING