Reference measurement procedure development for C-reactive protein in human serum.

@article{Kilpatrick2009ReferenceMP,
  title={Reference measurement procedure development for C-reactive protein in human serum.},
  author={Eric L. Kilpatrick and David M. Bunk},
  journal={Analytical chemistry},
  year={2009},
  volume={81 20},
  pages={
          8610-6
        }
}
This paper describes the development of a reference measurement procedure to quantify human C-reactive protein (CRP) in serum using affinity techniques prior to tryptic digestion and liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the certification of reference materials in clinically relevant ranges. The absence of a suitable internal standard for the CRP measurement, necessary to eliminate potential measurement bias in both the affinity purification and trypsin digestion steps… 
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Methods Citations
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