Reference intervals for immature platelet fraction and immature platelet count

@article{Seo2015ReferenceIF,
  title={Reference intervals for immature platelet fraction and immature platelet count},
  author={Andrew Seo and Deborah Yuan and Sarah Daniels and Shan Yuan and Mary Gallagher and Edward Wong},
  journal={International Journal of Laboratory Hematology},
  year={2015},
  volume={37}
}
  • A. Seo, D. Yuan, E. Wong
  • Published 1 February 2015
  • Medicine, Biology
  • International Journal of Laboratory Hematology
Sir, The recovery of platelet count is often used as an indicator of thrombopoiesis recovery after chemotherapy or hematopoietic progenitor cell transplantation. Flow cytometry has been used to follow the return of thrombopoiesis by identifying reticulated platelets [1]. This technique requires expensive instrumentation and manual manipulation and is very time-consuming and not readily available in all laboratories. The XE-2100/XE5000 hematology analyzer measures immature platelet fraction (IPF… 
Clinical Utility of Immature Platelet Fraction - An Advanced Parameter in Laboratory Hematology.
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  • Biology, Medicine
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • 2016
TLDR
In patients with thrombocytopenia, count alone does not provide precise assessment of bleeding risk and platelet production from bone marrow, and immature platelets or reticulated platelets are young platelets that circulate in the peripheral blood and provide functional status of platelets production by bone marrow.
Combined Immature Platelet Fraction and Schistocyte Count to Differentiate Pregnancy-Associated Thrombotic Thrombocytopenic Purpura from Severe Preeclampsia/Haemolysis, Elevated Liver Enzymes, and Low Platelet Syndrome (SPE/HELLP)
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IPF% and schistocyte counts were able to discriminate between TMA patients and normal pregnant women, and between and SPE/HELLP and TTP patients, and the discriminatory function of each was improved when the two parameters were used in combination.
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TLDR
The new reference intervals for IPF and absolute number of IPF (A-IPF) on Sysmex XN would provide fundamental data for clinical practice and future research.
Reference interval for immature platelet fraction on Sysmex XN haematology analyser in adult population
TLDR
This study provides, for the first time, a reference interval for IPF using a Sysmex XN-2000 in a Spanish population, ranging from 1.6 to 9.6%, needed to evaluate platelet production in several conditions such as thrombocytopenia, inflammatory states and cardiovascular diseases, as well as for future research.
Utility of the immature platelet fraction in pediatric immune thrombocytopenia: Differentiating from bone marrow failure and predicting bleeding risk
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Two small studies have suggested that immature platelet fraction (IPF) may differentiate ITP from other causes of thrombocytopenia and in combination with other factors may predict bleeding risk.
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  • E. Wong
  • Medicine
    Clinics in laboratory medicine
  • 2015
Differential Diagnosis of Thrombocytopenia
TLDR
There are three diagnostic cornerstones for diagnosing ITP – patient history, physical examination, and peripheral blood smear confirming thrombocytopenia to exclude pseudothrombocytes topenia.

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Results show that a rapid, inexpensive automated method for measuring the IPF% is feasible and should become a standard parameter in evaluating the thrombocytopenic patient.
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The immature platelet fraction (IPF) or the absolute immature platelets count (AIPC) may predict platelet count recovery following chemotherapy‐induced thrombocytopenia in pediatric patients and help guiding prophylactic platelet transfusion therapy.
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