Reference intervals for immature platelet fraction and immature platelet count

  title={Reference intervals for immature platelet fraction and immature platelet count},
  author={Andrew Seo and Deborah Yuan and Sarah Daniels and Shan Yuan and Mary Gallagher and Edward Wong},
  journal={International Journal of Laboratory Hematology},
  • A. Seo, D. Yuan, E. Wong
  • Published 1 February 2015
  • Medicine, Biology
  • International Journal of Laboratory Hematology
Sir, The recovery of platelet count is often used as an indicator of thrombopoiesis recovery after chemotherapy or hematopoietic progenitor cell transplantation. Flow cytometry has been used to follow the return of thrombopoiesis by identifying reticulated platelets [1]. This technique requires expensive instrumentation and manual manipulation and is very time-consuming and not readily available in all laboratories. The XE-2100/XE5000 hematology analyzer measures immature platelet fraction (IPF… 
Clinical Utility of Immature Platelet Fraction - An Advanced Parameter in Laboratory Hematology.
  • S. Ali, M. S. Shaikh
  • Biology, Medicine
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • 2016
In patients with thrombocytopenia, count alone does not provide precise assessment of bleeding risk and platelet production from bone marrow, and immature platelets or reticulated platelets are young platelets that circulate in the peripheral blood and provide functional status of platelets production by bone marrow.
Combined Immature Platelet Fraction and Schistocyte Count to Differentiate Pregnancy-Associated Thrombotic Thrombocytopenic Purpura from Severe Preeclampsia/Haemolysis, Elevated Liver Enzymes, and Low Platelet Syndrome (SPE/HELLP)
IPF% and schistocyte counts were able to discriminate between TMA patients and normal pregnant women, and between and SPE/HELLP and TTP patients, and the discriminatory function of each was improved when the two parameters were used in combination.
Reference interval for immature platelet fraction on Sysmex XN hematology analyzer: a comparison study with Sysmex XE-2100
The new reference intervals for IPF and absolute number of IPF (A-IPF) on Sysmex XN would provide fundamental data for clinical practice and future research.
Reference interval for immature platelet fraction on Sysmex XN haematology analyser in adult population
This study provides, for the first time, a reference interval for IPF using a Sysmex XN-2000 in a Spanish population, ranging from 1.6 to 9.6%, needed to evaluate platelet production in several conditions such as thrombocytopenia, inflammatory states and cardiovascular diseases, as well as for future research.
Utility of the immature platelet fraction in pediatric immune thrombocytopenia: Differentiating from bone marrow failure and predicting bleeding risk
Two small studies have suggested that immature platelet fraction (IPF) may differentiate ITP from other causes of thrombocytopenia and in combination with other factors may predict bleeding risk.
Hematology analyzers: special considerations for pediatric patients.
  • E. Wong
  • Medicine
    Clinics in laboratory medicine
  • 2015
Differential Diagnosis of Thrombocytopenia
There are three diagnostic cornerstones for diagnosing ITP – patient history, physical examination, and peripheral blood smear confirming thrombocytopenia to exclude pseudothrombocytes topenia.


Assessment of an immature platelet fraction (IPF) in peripheral thrombocytopenia
Results show that a rapid, inexpensive automated method for measuring the IPF% is feasible and should become a standard parameter in evaluating the thrombocytopenic patient.
Quantitation of reticulated platelets: methodology and clinical application
The course of the reticulated platelet percentage (RP%) in patients with resolving thrombocytopenic states is described, contrasting the elevation seen in consumptive disorders with the fall in aplastic states.
Automatic detection of immature platelets for decision making regarding platelet transfusion indications for pediatric patients.
  • K. Saigo, Yasuyuki Sakota, S. Kumagai
  • Medicine
    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
  • 2008
Correlation between immature platelet fraction and reticulated platelets. Usefulness in the etiology diagnosis of thrombocytopenia
This work analyzed the correlation between IPF and RP, and usefulness of IPF in patients with thrombocytopenia.
Absolute immature platelet count may predict imminent platelet recovery in thrombocytopenic children following chemotherapy
The immature platelet fraction (IPF) or the absolute immature platelets count (AIPC) may predict platelet count recovery following chemotherapy‐induced thrombocytopenia in pediatric patients and help guiding prophylactic platelet transfusion therapy.
Immature platelet count: A simple parameter for distinguishing thrombocytopenia in pediatric acute lymphocytic leukemia from immune thrombocytopenia
This preliminary study evaluates whether one of these markers can be used for diagnosis of isolated thrombocytopenia in children.
The purpose of this article is to describe a few statistical tools and to illustrate how these tools may be useful in the practice of medicine.
Measurement of the absolute immature platelet number reflects marrow production and is not impacted by platelet transfusion
The ability to distinguish increased platelet (PLT) destruction from PLT hypoproduction is important in the care of patients with marrow failure syndromes and patients receiving high‐dose
Pediatric Reference Intervals, 7th edn
  • 2011