Reference Profile Correlation Reveals Estrogen-like Trancriptional Activity of Curcumin

  title={Reference Profile Correlation Reveals Estrogen-like Trancriptional Activity of Curcumin},
  author={Beatrice E Bachmeier and Valentina Mirisola and Francesco Romeo and Luca Generoso and Alessia Isabella Esposito and Raffaella Dell’eva and Fabiola Blengio and Peter H. Killian and Adriana Albini and Ulrich Pfeffer},
  journal={Cellular Physiology and Biochemistry},
  pages={471 - 482}
Background: Several secondary metabolites from herbal nutrient products act as weak estrogens (phytoestrogens), competing with endogenous estrogen for binding to the estrogen receptors and inhibiting steroid converting enzymes. However, it is still unclear whether these compounds elicit estrogen dependent transcription of genes at physiological concentrations. Methods: We compare the effects of physiological concentrations (100 nM) of the two phytoestrogens Enterolactone and Quercetin and the… 

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