Ref-1 controls pax-8 DNA-binding activity.

  title={Ref-1 controls pax-8 DNA-binding activity.},
  author={Gianluca Tell and Lucia Pellizzari and D Cimarosti and Carlo Pucillo and Giuseppe Damante},
  journal={Biochemical and biophysical research communications},
  volume={252 1},
Redox potential controls the DNA-binding activity of several transcription factors. In some cases, the regulation of DNA-binding activity by the redox state is mediated by the Ref-1 nuclear protein. In this study, we demonstrate that Ref-1 is able to induce "in vitro" the DNA-binding activity of the Pax-8 paired domain. In co-transfection experiments, Ref-1… CONTINUE READING