Reexamination of paternal age effect in Down's syndrome

@article{Roth1983ReexaminationOP,
  title={Reexamination of paternal age effect in Down's syndrome},
  author={Monika Roth and Josu{\'e} Feingold and Andrea Baumgarten and Paul Bigel and Claude Stoll},
  journal={Human Genetics},
  year={1983},
  volume={63},
  pages={149-152}
}
The recent discovery that the extra chromosome in about 30% of cases of 47, trisomy 21 is of paternal origin has revived interest in the possibility of paternal age as a risk factor for a Down syndrome birth, independent of maternal age. Parental age distribution for 611 Down's syndrome 47,+21 cases was studied. The mean paternal age was 0.16 year greater than in the entire population of live births after controlling for maternal age. There was no evidence for a significant paternal age effect… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Is there a paternal age effect for aneuploidy?

Cytogenetic and genome research • 2011
View 1 Excerpt

Reproductive functions of the ageing male.

Human reproduction update • 2004
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 18 references

Parental factors in Down's syndrome--results of the second Baltimore case-control study. In: Hook EB, Porter IH (eds) Population cytogenetics: Studies in humans

BH Cohen, AM Lilienfeld, S Kramer, LC Hyman
1977
View 9 Excerpts
Highly Influenced

Paternal age and Down syndrome in British Columbia.

American journal of human genetics • 1981
View 5 Excerpts
Highly Influenced

Paternal age effect in Down's syndrome.

View 4 Excerpts
Highly Influenced

Paternal age and Down syndrome.

American journal of human genetics • 1979
View 2 Excerpts

Similar Papers

Loading similar papers…