Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na⁺/K⁺-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascades.

@article{Chan2013ReevesiosideFI,
  title={Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na⁺/K⁺-ATPase $\alpha$3 subunit-involved mitochondrial stress and amplification of caspase cascades.},
  author={She-Hung Chan and Wohn-Jenn Leu and L. C. Hsu and Hsun-Shuo Chang and Tsong-Long Hwang and Ih-Sheng Chen and Ching Shih Chen and Jih-Hwa Guh},
  journal={Biochemical pharmacology},
  year={2013},
  volume={86 11},
  pages={
          1564-75
        }
}
Epi-reevesioside F inhibits Na+/K+-ATPase, causing cytosolic acidification, Bak activation and apoptosis in glioblastoma
TLDR
The data suggest that Epi-reevesioside F inhibits Na+/K+-ATPase, leading to overload of intracellular Na+ and cytosolic acidification, Bak activation and loss of mitochondrial membrane potential, and the PI3-kinase/Akt pathway is inhibited and caspase-dependent apoptosis is ultimately triggered in Epi -reevesioide F-treated glioblastoma cells.
Ferula pseudalliacea induces apoptosis in human colorectal cancer HCT-116 cells via mitochondria-dependent pathway
TLDR
It is demonstrated that F. pseudalliacea extract is able to induce apoptosis in HCT-116 cells mainly by activation of the mitochondrial pathway.
Mitomycin C Induces Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes via a Mitochondrial-Mediated Pathway
TLDR
The findings suggest that MMC inhibits cell proliferation and induces apoptosis in RA FLS, and the mechanism underlying this MMC-induced apoptosis may involve a mitochondrial signalling pathway.
Cytotoxicity of cardiotonic steroids in sensitive and multidrug-resistant leukemia cells and the link with Na+/K+-ATPase
Cardiac glycosides: From molecular targets to immunogenic cell death
Oleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway
TLDR
The results suggest that the anticancer effects of oleandrin and odoroside A might be due to the inhibition of invasion through of phospho-STAT-3-mediated pathways that are involved in the regulation of invasion-related molecules.
Cytotoxic effects of hydroalcoholic extract of Cuscuta chinensis on PC3 and MCF7 cancer cell lines
TLDR
The findings suggest that C. chinensis extract is able to inhibit proliferation and induce apoptosis in PC3 and MCF7 cell lines and exerts antitumor activity against cancer cells.
Bioactive composition of Reevesia formosana root and stem with cytotoxic activity potential
Six new compounds including three lignanoids: reevesiacoumarin (1), reevesic acid (2), and reevesilignan (3), and three terpenoids: reevesiterpenol A (4), reevesiterpenol B (5), and
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