Reevaluation of the striatal role in the expression of turning behavior in the rat model of Parkinson's disease.

@article{Mura1998ReevaluationOT,
  title={Reevaluation of the striatal role in the expression of turning behavior in the rat model of Parkinson's disease.},
  author={Anna Mura and Joram Feldon and Matti Mintz},
  journal={Brain research},
  year={1998},
  volume={808 1},
  pages={48-55}
}
A traditional view holds the belief that the behavioral effects of l-dihydroxyphenilalanine (l-DOPA) in Parkinsonian patients are achieved through the action of the newly produced dopamine (DA) on striatal DA receptors. In contrast to this view, recent studies in the rat model of Parkinson's disease point to the substantia nigra pars reticulata as an important target for the behavioral effects of l-DOPA. In the present study, we tested the contribution of the substantia nigra vs. that of the… CONTINUE READING