Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population.

@article{Morgan2009ReevaluationOT,
  title={Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population.},
  author={Ann W Morgan and Wendy Thomson and Stephen G. Martin and Angela M. Carter and Henry A. Erlich and Anne Barton and Lynne J. Hocking and David M. Reid and Pille Harrison and Paul Wordsworth and Sophia Steer and Julian Worthington and Paul Emery and Anthony G Wilson and Jennifer H. Barrett},
  journal={Arthritis and rheumatism},
  year={2009},
  volume={60 9},
  pages={
          2565-76
        }
}
OBJECTIVE To define interactions between the HLA-DRB1 shared epitope (SE), PTPN22, and smoking in cyclic citrullinated peptide (CCP) antibody- and rheumatoid factor (RF)-positive and -negative rheumatoid arthritis (RA). METHODS Data on approximately 5,000 RA patients and approximately 3,700 healthy controls recruited from 6 centers in the UK were analyzed; not all centers had both genotype data and smoking data available for study. The magnitude of association was assessed in autoantibody… CONTINUE READING
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