Reevaluation of the definition of Legionnaires' disease: use of the urinary antigen assay. Community Based Pneumonia Incidence Study Group.

@article{Plouffe1995ReevaluationOT,
  title={Reevaluation of the definition of Legionnaires' disease: use of the urinary antigen assay. Community Based Pneumonia Incidence Study Group.},
  author={Joseph F Plouffe and Thomas M. File and Robert F. Breiman and Barbara A. Hackman and S J Salstrom and Barbara J. Marston and Barry S. Fields},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={1995},
  volume={20 5},
  pages={1286-91}
}
Cases of Legionnaires' disease have been categorized as definitive and presumptive. The sensitivity and specificity of antibody titers of > or = 256 and of urinary antigen ratios of > or = 3 were evaluated in 68 patients with "definitive" Legionnaires' disease and in 636 patients with pneumonia who had negative cultures and did not have fourfold rises in titers of antibody to Legionella pneumophila. An acute-phase antibody titer of > or = 256 did not discriminate between cases and noncases (10… CONTINUE READING

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