Reevaluation of the beam and radial hypotheses of parallel fiber action in the cerebellar cortex.

@article{Cramer2013ReevaluationOT,
  title={Reevaluation of the beam and radial hypotheses of parallel fiber action in the cerebellar cortex.},
  author={Samuel W Cramer and Wangcai Gao and Gang Chen and Timothy J Ebner},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 28},
  pages={11412-24}
}
The role of parallel fibers (PFs) in cerebellar physiology remains controversial. Early studies inspired the "beam" hypothesis whereby granule cell (GC) activation results in PF-driven, postsynaptic excitation of beams of Purkinje cells (PCs). However, the "radial" hypothesis postulates that the ascending limb of the GC axon provides the dominant input to PCs and generates patch-like responses. Using optical imaging and single-cell recordings in the mouse cerebellar cortex in vivo, this study… CONTINUE READING
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