Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action.

@article{Cian2007ReevaluationOT,
  title={Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action.},
  author={Anne De Cian and Gael Cristofari and Patrick Reichenbach and Elsa de Lemos and David Monchaud and Marie-Paule Teulade-Fichou and Kazuo Shin-Ya and Laurent Lacroix and Joachim Lingner and Jean-Louis Mergny},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 44},
  pages={17347-52}
}
Quadruplex ligands are often considered as telomerase inhibitors. Given the fact that some of these molecules are present in the clinical setting, it is important to establish the validity of this assertion. To analyze the effects of these compounds, we used a direct assay with telomerase-enriched extracts. The comparison of potent ligands from various chemical families revealed important differences in terms of effects on telomerase initiation and processivity. Although most quadruplex ligands… CONTINUE READING

From This Paper

Topics from this paper.
43 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

Similar Papers

Loading similar papers…