Reevaluation of a quantitative structure pharmacokinetic model for biliary excretion in rats.

@article{Gandhi2012ReevaluationOA,
  title={Reevaluation of a quantitative structure pharmacokinetic model for biliary excretion in rats.},
  author={Yash A. Gandhi and Marilyn E Morris},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2012},
  volume={40 7},
  pages={
          1259-62
        }
}
Quantitative structure pharmacokinetic relationship (QSPKR) modeling can be used to predict the biliary clearance and percentage of dose eliminated in bile (PD(b)) in humans before clinical studies. Recently, a QSPKR model based on in-house compounds was derived using simple physicochemical descriptors to predict the PD(b) in rats (Drug Metab Dispos 38:422-430, 2010). Our objective was to evaluate the QSPKR model derived for the prediction of PD(b) for our larger dataset of 164 compounds in the… CONTINUE READING

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-2 OF 2 CITATIONS

Estimation of Biliary Excretion of Foreign Compounds Using Properties of Molecular Structure

  • The AAPS Journal
  • 2013
VIEW 5 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

Effect of OATP-binding on the prediction of biliary excretion.

  • Xenobiotica; the fate of foreign compounds in biological systems
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 11 REFERENCES

In silico prediction of biliary excretion of drugs in rats based on physicochemical properties.

  • Drug metabolism and disposition: the biological fate of chemicals
  • 2010
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

Structure-pharmacokinetic relationship of in vivo rat biliary excretion.

  • Biopharmaceutics & drug disposition
  • 2010
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…