Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).

@article{Chien2018ReevaluatingTS,
  title={Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).},
  author={Huan-Chieh Chien and Claire Colas and Karissa Finke and Seth Springer and Laura Stoner and Arik A. Zur and Brooklynn Venteicher and Jerome Campbell and Colton Hall and Andrew J. Flint and Evan Augustyn and Christopher Hernandez and Nathan Heeren and Logan Hansen and Abby Anthony and Justine Bauer and Dimitrios Fotiadis and Avner Schlessinger and Kathleen M. Giacomini and Allen A Thomas},
  journal={Journal of medicinal chemistry},
  year={2018},
  volume={61 16},
  pages={
          7358-7373
        }
}
The L-type amino acid transporter 1 (LAT1, SLC7A5) transports essential amino acids across the blood-brain barrier (BBB) and into cancer cells. To utilize LAT1 for drug delivery, potent amino acid promoieties are desired, as prodrugs must compete with millimolar concentrations of endogenous amino acids. To better understand ligand-transporter interactions that could improve potency, we developed structural LAT1 models to guide the design of substituted analogues of phenylalanine and histidine… CONTINUE READING
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