Reengineering of a fluorescent zinc sensor protein yields the first genetically encoded cadmium probe.

@article{Vinkenborg2011ReengineeringOA,
  title={Reengineering of a fluorescent zinc sensor protein yields the first genetically encoded cadmium probe.},
  author={Jan L. Vinkenborg and Sander M. J. van Duijnhoven and Maarten Merkx},
  journal={Chemical communications},
  year={2011},
  volume={47 43},
  pages={11879-81}
}
Introduction of a (Cys)(4) metal binding site at the dimerization interface of two fluorescent protein domains yields a chelating FRET sensor protein that shows a 2500-fold selectivity for Cd(2+) over Zn(2+) by taking advantage of their different ionic radii. 
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