Reemergence of enterovirus 71 in 2008 in taiwan: dynamics of genetic and antigenic evolution from 1998 to 2008.

@article{Huang2009ReemergenceOE,
  title={Reemergence of enterovirus 71 in 2008 in taiwan: dynamics of genetic and antigenic evolution from 1998 to 2008.},
  author={Sheng-Wen Huang and Yun-Wei A Hsu and Derek J. Smith and David Kiang and H P Tsai and Kuei-Hsiang Lin and S M Wang and Ching-Chung Liu and I Fan Su and Jen-Ren Wang},
  journal={Journal of clinical microbiology},
  year={2009},
  volume={47 11},
  pages={3653-62}
}
In recent years, enterovirus 71 (EV71) has been a cause of numerous outbreaks of hand-foot-and-mouth disease, with severe neurological complications in the Asia-Pacific region. The reemergence in Taiwan of EV71 genotype B5 in 2008 resulted in the largest outbreak of EV71 in Taiwan in the past 11 years. Phylogenetic analyses indicated that dominant genotype changes from B to C or C to B occurred at least three times between 1986 and 2008. Furthermore, antigenic cartography of EV71 by using… CONTINUE READING
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