Reelin promoter hypermethylation in schizophrenia.

  title={Reelin promoter hypermethylation in schizophrenia.},
  author={Dennis R. Grayson and Xiaomei Jia and Yin Chen and Rajiv P. Sharma and Colin P Mitchell and Alessandro Guidotti and Erminio Costa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 26},
Reelin mRNA and protein levels are reduced by approximately 50% in various cortical structures of postmortem brain from patients diagnosed with schizophrenia or bipolar illness with psychosis. In addition, the mRNA encoding the methylating enzyme, DNA methyltransferase 1, is up-regulated in the same neurons that coexpress reelin and glutamic acid decarboxylase 67. We have analyzed the extent and pattern of methylation within the CpG island of the reelin promoter in genomic DNA isolated from… CONTINUE READING