Reelin glycoprotein: structure, biology and roles in health and disease

  title={Reelin glycoprotein: structure, biology and roles in health and disease},
  author={S Hossein Fatemi},
  journal={Molecular Psychiatry},
  • S. Fatemi
  • Published 1 March 2005
  • Biology, Psychology
  • Molecular Psychiatry
Reelin glycoprotein is a secretory serine protease with dual roles in mammalian brain: embryologically, it guides neurons and radial glial cells to their corrected positions in the developing brain; in adult brain, Reelin is involved in a signaling pathway which underlies neurotransmission, memory formation and synaptic plasticity. Disruption of Reelin signaling pathway by mutations and selective hypermethylation of the Reln gene promoter or following various pre- or postnatal insults may lead… 
Reelin and its complex involvement in brain development and function.
The Role of Reelin Signaling in Alzheimer’s Disease
The present review briefly summarizes the current knowledge and recent findings related to the molecular link between Reelin dysfunction and AD-related neuropathology.
Reelin glycoprotein in autism and schizophrenia.
  • S. Fatemi
  • Psychology, Medicine
    International review of neurobiology
  • 2005
Reelin, a Marker of Stress Resilience in Depression and Psychosis
Activation of the Reelin signaling pathway leads to various, important functions such as enhancement of long-term potentiation, cell proliferation, cell migration, and more importantly dendritic spine morphogenesis.
Reelin Depletion in the Entorhinal Cortex of Human Amyloid Precursor Protein Transgenic Mice and Humans with Alzheimer's Disease
Altered Reelin levels might be altered in the brains of human amyloid precursor protein (hAPP) transgenic mice, particularly in brain regions vulnerable to AD such as hippocampus and entorhinal cortex, to conclude that alterations in Reelin processing or signaling may be involved in AD-related neuronal dysfunction.
Chemistry of Reelin
The current state of knowledge on the best established and some other putative partners of the Reelin pathway are reviewed.
Reelin modulates cytoskeletal organization by regulating Rho GTPases
The finding that Reelin activates Rho GTPases in neurons is discussed in the light of other recent studies, which demonstrate a role of Reelin in Golgi organization, and additional roles of Cdc42 activation by Reelin are suggested in radial glial cells of the developing cortex.
The role of RELN in lissencephaly and neuropsychiatric disease
  • B. Chang, F. Duzcan, C. Walsh
  • Medicine, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2007
The findings demonstrate the distinctive phenotype of LCH, which is easily distinguishable from other forms of lissencephaly, and its role, if any, in the pathogenesis of psychiatric disorders remains unclear.


Interaction of reelin signaling and Lis1 in brain development
Interactions between the reelin signaling pathway and Lis1 in brain development are investigated and Dab1 and Lis 1 bound in a reelin-induced phosphorylation-dependent manner, indicating genetic and biochemical interaction between the self-reinforcing pathways.
A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
The reeler phenotype seems to reflect a failure of early events associated with brain lamination which are normally controlled by reelin.
Reelin, Disabled 1, and β1 integrins are required for the formation of the radial glial scaffold in the hippocampus
It is shown that a regular glial scaffold fails to form in vivo in the dentate gyrus of mice deficient of Reelin or Disabled 1, a neuronal adaptor protein in the Reelin signaling pathway, and data suggest that Reelin affects glial differentiation via Disabled 1 and β1-class integrin-dependent signaling pathways.
Reelin Is a Secreted Glycoprotein Recognized by the CR-50 Monoclonal Antibody
It is demonstrated that Reelin is a secreted glycoprotein and that a highly charged C-terminal region is essential for secretion and that an amino acid sequence present in the N- terminal region of Reelin contains an epitope that is recognized by the CR-50 monoclonal antibody.
Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer's disease
The presence of detectable levels of reelin in rat and human cerebrospinal fluid (CSF) and evidence for the involvement of a 180‐kDa reelin fragment in two neurodegenerative disorders are reported, for the first time.
Reelin Is a Ligand for Lipoprotein Receptors
Reelin and Disabled‐1 Expression in Developing and Mature Human Cortical Neurons
The novel finding that human DAB1 and RELN are coexpressed in CR neurons during cortical development and in cortical pyramidal neurons after neuronal migration is complete is reported.