Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus.

@article{Heinrich2006ReelinDA,
  title={Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus.},
  author={Christophe Heinrich and Naoki Nitta and Armin Flubacher and Martin M{\"u}ller and Alexander Fahrner and Matthias Kirsch and Thomas M. Freiman and Fumio Suzuki and Antoine Depaulis and Michael Frotscher and Carola A Haas},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 17},
  pages={4701-13}
}
Mesio-temporal lobe epilepsy (MTLE) is often accompanied by granule cell dispersion (GCD), a widening of the granule cell layer. The molecular determinants of GCD are poorly understood. Here, we used an animal model to study whether GCD results from an increased dentate neurogenesis associated with an abnormal migration of the newly generated granule cells. Adult mice were given intrahippocampal injections of kainate (KA) known to induce focal epileptic seizures and GCD, comparable to the… CONTINUE READING
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