Reed-Sternberg cells of classical Hodgkin's disease react with the plasma cell-specific monoclonal antibody B-B4 and express human syndecan-1.

@article{Carbone1997ReedSternbergCO,
  title={Reed-Sternberg cells of classical Hodgkin's disease react with the plasma cell-specific monoclonal antibody B-B4 and express human syndecan-1.},
  author={Antonino Carbone and Annunziata Gloghini and Valter Gattei and Massimo Degan and S Improta and Donatella Aldinucci and Vincenzo Canzonieri and Tiziana Perin and Rachele Volpe and Gianluca Gaidano and Vittorina Zagonel and Ant{\'o}nio Pinto},
  journal={Blood},
  year={1997},
  volume={89 10},
  pages={3787-94}
}
Although the cellular origin of Reed-Sternberg (RS) cells of classical Hodgkin's disease (HD) has been a controversial issue for many years, recent immunophenotypic and molecular studies have suggested that RS cells of a subset of classical HD cases may be related to B cells. To further define the immunophenotypic features and the differentiation stage of RS cells, a series of 56 HD samples, including both nodular lymphocyte predominance (LP) (eight cases) and classical HD (nodular sclerosis… CONTINUE READING