Redundant role for Zap70 in B cell development and activation.

@article{FallahArani2008RedundantRF,
  title={Redundant role for Zap70 in B cell development and activation.},
  author={Farnaz Fallah-Arani and Edina Schweighoffer and Lesley Vanes and Victor L. J. Tybulewicz},
  journal={European journal of immunology},
  year={2008},
  volume={38 6},
  pages={1721-33}
}
Expression of the Syk family tyrosine kinase Zap70 is strongly correlated with poor clinical outcome in chronic lymphocytic leukemia, the most common human leukemia characterized by B cell accumulation. The expression of Zap70 may reflect the specific cell of origin of the tumor or may contribute to pathology. Thus, the normal role of Zap70 in B cell… CONTINUE READING