Redundant and specialized roles for diacylglycerol kinases α and ζ in the control of T cell functions

@article{Mrida2015RedundantAS,
  title={Redundant and specialized roles for diacylglycerol kinases α and ζ in the control of T cell functions},
  author={Isabel M{\'e}rida and Elena Andrada and Severine I. Gharbi and Antonia {\'A}vila-Flores},
  journal={Science Signaling},
  year={2015},
  volume={8},
  pages={re6-re6}
}
The diacylglycerol kinases (DGKs) attenuate diacylglycerol (DAG)–mediated signals by catalyzing the conversion of DAG to phosphatidic acid. In T lymphocytes, the antigen-stimulated generation of DAG links signal strength to the intensity and duration of signaling by the Ras–extracellular signal–regulated kinase (ERK) and protein kinase C (PKC)–dependent pathways. The generation of DAG at the plasma membrane of T cells lies at the core of the mechanisms that delimit T cell functions. DGKα and… CONTINUE READING

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