Redundancy of Cav2.1 channel accessory subunits in transmitter release at the mouse neuromuscular junction.

@article{Kaja2007RedundancyOC,
  title={Redundancy of Cav2.1 channel accessory subunits in transmitter release at the mouse neuromuscular junction.},
  author={Simon Kaja and Boyan Todorov and Rob C G van de Ven and Michel D. Ferrari and Rune R. Frants and Arn M J M van den Maagdenberg and Jaap J. Plomp},
  journal={Brain research},
  year={2007},
  volume={1143},
  pages={92-101}
}
Ca(v)2.1 (P/Q-type) channels possess a voltage-sensitive pore-forming alpha(1) subunit that can associate with the accessory subunits alpha(2)delta, beta and gamma. The primary role of Ca(v)2.1 channels is to mediate transmitter release from nerve terminals both in the central and peripheral nervous system. Whole-cell voltage-clamp studies in in vitro expression systems have indicated that accessory channel subunits can have diverse modulatory effects on membrane expression and biophysical… CONTINUE READING

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