Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype.

@article{Sospedra2006RedundancyIA,
  title={Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype.},
  author={Mireia Sospedra and Paolo Antonio Muraro and Irena {\vS}tefanov{\'a} and Yingdong Zhao and Katherine S. Cennamo Sandra K. Abell Mi - Lee Chung and Yili Li and Marc A. Giulianotti and Richard Simon and Roy A. Mariuzza and Clemencia Pinilla and Roland Martin},
  journal={Journal of immunology},
  year={2006},
  volume={176 3},
  pages={1951-61}
}
The three HLA class II alleles of the DR2 haplotype, DRB1*1501, DRB5*0101, and DQB1*0602, are in strong linkage disequilibrium and confer most of the genetic risk to multiple sclerosis. Functional redundancy in Ag presentation by these class II molecules would allow recognition by a single TCR of identical peptides with the different restriction elements, facilitating T cell activation and providing one explanation how a disease-associated HLA haplotype could be linked to a CD4+ T cell-mediated… CONTINUE READING
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tiple sclerosis : a modifying influence of HLA class I genes in an HLA class II associated autoimmune disease

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