Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily

@inproceedings{Jeon2007RedundancyAC,
  title={Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily},
  author={Mili Jeon and Huong Nguyen and Sami M. Bahri and Kai Zinn},
  booktitle={Neural Development},
  year={2007}
}
Drosophila has six receptor protein tyrosine phosphatases (RPTPs), five of which are expressed primarily in neurons. Mutations in all five affect axon guidance, either alone or in combination. Highly penetrant central nervous system (CNS) and motor axon guidance alterations are usually observed only when specific combinations of two or more RPTPs are removed. Here, we examine the sixth RPTP, Ptp4E, which is broadly expressed. Ptp4E and Ptp10D are closely related type III RPTPs. Non-drosophilid… CONTINUE READING

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