Reductive metabolism of aromatic nitro compounds including carcinogens by rabbit liver preparations.

@article{Tatsumi1986ReductiveMO,
  title={Reductive metabolism of aromatic nitro compounds including carcinogens by rabbit liver preparations.},
  author={Kiyoshi Tatsumi and Shigeyuki Kitamura and Noriko Narai},
  journal={Cancer research},
  year={1986},
  volume={46 3},
  pages={1089-93}
}
Reductive metabolism of aromatic nitro compounds was examined with rabbit liver preparations. Under anaerobic conditions, carcinogenic 2-nitrofluorene, 4-nitrobiphenyl, and 1-nitro-naphthalene were reduced to the corresponding hydroxylamines and amines, whereas the carcinogenic 1-nitropyrene was reduced only to the corresponding amine by liver cytosol in the presence of 2-hydroxypyrimidine, an electron donor of aldehyde oxidase. These metabolites were identified unequivocally by comparing their… CONTINUE READING
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