Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis.

@article{Serwold2009ReductiveIF,
  title={Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis.},
  author={Thomas Serwold and Lauren I R Ehrlich and Irving L Weissman},
  journal={Blood},
  year={2009},
  volume={113 4},
  pages={807-15}
}
Ongoing thymopoiesis requires continual seeding from progenitors that reside within the bone marrow (BM), but the identity of the most proximate prethymocytes has remained controversial. Here we take a comprehensive approach to prospectively identify the major source of thymocyte progenitors that reside within the BM and blood, and find that all thymocyte progenitor activity resides within a rare Flk2(+)CD27(+) population. The BM Flk2(+)CD27(+) subset is predominantly composed of common… CONTINUE READING