Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

  title={Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia},
  author={Christian M. Metallo and Paulo A. Gameiro and Eric L. Bell and Katherine R. Mattaini and Juanjuan Yang and Karsten Hiller and Christopher M Jewell and Zachary R. Johnson and Darrell J Irvine and Leonard Guarente and Joanne K. Kelleher and Matthew G. Vander Heiden and Othon Iliopoulos and Gregory Stephanopoulos},
Acetyl coenzyme A (AcCoA) is the central biosynthetic precursor for fatty-acid synthesis and protein acetylation. In the conventional view of mammalian cell metabolism, AcCoA is primarily generated from glucose-derived pyruvate through the citrate shuttle and ATP citrate lyase in the cytosol. However, proliferating cells that exhibit aerobic glycolysis and those exposed to hypoxia convert glucose to lactate at near-stoichiometric levels, directing glucose carbon away from the tricarboxylic acid… CONTINUE READING
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Oncogenic KRas decouples glucose and glutaminemetabolism to support cancer cell growth

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