Reductive depolymerization of bovine thyroglobulin multimers via enzymatic reduction of protein disulfide and glutathionylated mixed disulfide linkages.

Abstract

The nascent thyroglobulin (Tg) multimer molecule, which is generated during the initial fate of Tg in ER, undergoes the rapid reductive depolymerization. In an attempt to determine the depolymerization process, various types of Tg multimers, which were generated from deoxycholate-treated/reduced Tg, partially unfolded Tg or partially unfolded/reduced Tg… (More)

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