Reductive couplings of 2-halopyridines without external ligand: phosphine-free nickel-catalyzed synthesis of symmetrical and unsymmetrical 2,2'-bipyridines.

@article{Liao2014ReductiveCO,
  title={Reductive couplings of 2-halopyridines without external ligand: phosphine-free nickel-catalyzed synthesis of symmetrical and unsymmetrical 2,2'-bipyridines.},
  author={Lian-Yan Liao and Xing-Rui Kong and Xin-Fang Duan},
  journal={The Journal of organic chemistry},
  year={2014},
  volume={79 2},
  pages={777-82}
}
An unexpectedly facile synthetic approach for symmetrical and unsymmetrical 2,2'-bipyridines through the Ni-catalyzed reductive couplings of 2-halopyridines was developed. The couplings were efficiently catalyzed by 5 mol % of NiCl2·6H2O without the use of external ligands. A variety of 2,2'-bipyridines including caerulomycin F have been efficiently… CONTINUE READING