Reductions in systolic blood pressure with liraglutide in patients with type 2 diabetes: insights from a patient-level pooled analysis of six randomized clinical trials.

@article{Fonseca2014ReductionsIS,
  title={Reductions in systolic blood pressure with liraglutide in patients with type 2 diabetes: insights from a patient-level pooled analysis of six randomized clinical trials.},
  author={Vivian A. Fonseca and J. Hans DeVries and Robert R. Henry and Morten Donsmark and Henrik F. Thomsen and Jorge Plutzky},
  journal={Journal of diabetes and its complications},
  year={2014},
  volume={28 3},
  pages={399-405}
}
AIMS To quantify the effect of liraglutide on systolic blood pressure (SBP) and pulse in patients with type 2 diabetes (T2D), and assess the influence of covariates on observed SBP reductions. METHODS A patient-level pooled analysis of six phase 3, randomized trials was conducted. RESULTS The analysis included 2792 randomized patients. In the intention-to-treat population (n=2783), mean [±SE] SBP reductions from baseline with liraglutide 1.2 mg (2.7 [0.8] mmHg) and 1.8 mg (2.9 [0.7] mmHg… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

LEADER) Trial: Rationale and study design.Diabetes

  • J. B. Buse, J. Rosenstock, +4 authors H J.
  • 2009
Highly Influential
15 Excerpts

Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results — A long term evaluation (LEADER)

  • Novo Nordisk
  • Available at: http://clinicaltrials.gov/show…
  • 2013
Highly Influential
9 Excerpts

Trial to evaluate cardiovascular and other long-term outcomes with semaglutide in subjects with type 2 diabetes (SUSTAINTM 6)

  • Novo Nordisk
  • Available at: http://clinicaltrials.gov/ct2/show…
  • 2013
Highly Influential
9 Excerpts

Blood pressure outcomes with liraglutide therapy (BOLT)

  • Mount Sinai Hospital
  • Available at: http://clinicaltrials.gov/ct2/show…
  • 2013
2 Excerpts

Similar Papers

Loading similar papers…