Reductions in behavioral deficits and neuropathology in the R6/2 mouse model of Huntington’s disease following transplantation of bone-marrow-derived mesenchymal stem cells is dependent on passage number

@inproceedings{Rossignol2014ReductionsIB,
  title={Reductions in behavioral deficits and neuropathology in the R6/2 mouse model of Huntington’s disease following transplantation of bone-marrow-derived mesenchymal stem cells is dependent on passage number},
  author={Julien Rossignol and Kyle D Fink and Andrew T. Crane and Kendra K Davis and Matthew C Bombard and Steven Clerc and Angela M Bavar and Steven A. Lowrance and Cheng Song and Steven Witte and Laurent Lescaudron and Gary L Dunbar},
  booktitle={Stem Cell Research & Therapy},
  year={2014}
}
Huntington’s disease (HD) is an autosomal dominant disorder caused by an expanded CAG repeat (greater than 38) on the short arm of chromosome 4, resulting in loss and dysfunction of neurons in the neostriatum and cortex, leading to cognitive decline, motor dysfunction, and death, typically occurring 15 to 20 years after the onset of motor symptoms. Although an effective treatment for HD has remained elusive, current studies using transplants of bone-marrow-derived mesenchymal stem cells… CONTINUE READING
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