Reduction to homozygosity involving p53 in esophageal cancers demonstrated by the polymerase chain reaction.

Abstract

Loss of heterozygosity affecting chromosome 17p has been detected at high frequencies in a variety of human tumors, including cancers of the colon, breast, lung, and brain. One presumed target of these losses is p53, a tumor suppressor gene located on 17p. To our knowledge, loss of heterozygosity has not yet been reported at any locus, including p53, in… (More)

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Cite this paper

@article{Meltzer1991ReductionTH, title={Reduction to homozygosity involving p53 in esophageal cancers demonstrated by the polymerase chain reaction.}, author={Sara J. Meltzer and Jieyun Yin and Y. Huang and T. K. McDaniel and Cathy Newkirk and Ozlem Darcansoy Iseri and Barry N. Vogelstein and J. H. Resau}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1991}, volume={88 11}, pages={4976-80} }