Reduction to homozygosity involving p53 in esophageal cancers demonstrated by the polymerase chain reaction.

@article{Meltzer1991ReductionTH,
  title={Reduction to homozygosity involving p53 in esophageal cancers demonstrated by the polymerase chain reaction.},
  author={Stephen J. Meltzer and J. -H. Yin and Yong Huang and T. K. McDaniel and C Newkirk and Oscar A. Iseri and Bert Vogelstein and James H. Resau},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 11},
  pages={4976-80}
}
Loss of heterozygosity affecting chromosome 17p has been detected at high frequencies in a variety of human tumors, including cancers of the colon, breast, lung, and brain. One presumed target of these losses is p53, a tumor suppressor gene located on 17p. To our knowledge, loss of heterozygosity has not yet been reported at any locus, including p53, in human esophageal cancer. Moreover, current methods of detecting loss of heterozygosity depend on the availability of large amounts of high… CONTINUE READING
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