Reduction-oxidation (redox) state regulation of matrix metalloproteinase activity in human fetal membranes.

  title={Reduction-oxidation (redox) state regulation of matrix metalloproteinase activity in human fetal membranes.},
  author={Irina Alexandra Buhimschi and Wayne B. Kramer and Catalin Sorin Buhimschi and Loren P. Thompson and Carl P. Weiner},
  journal={American journal of obstetrics and gynecology},
  volume={182 2},
OBJECTIVE The mechanisms underlying membrane rupture at term and preterm are obscure. Collagenolytic activity of matrix metalloproteinases in amniochorionic membranes increases during spontaneous term and preterm labor associated with intra-amniotic infection. We sought to test the hypothesis that reduction-oxidation homeostasis, which is altered in inflammatory states, directly regulates amniochorionic matrix metalloproteinases. STUDY DESIGN Membranes were collected from 7 patients… CONTINUE READING


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