Reduction of type V collagen using a dominant-negative strategy alters the regulation of fibrillogenesis and results in the loss of corneal- specific fibril morphology

@article{Marchant1996ReductionOT,
  title={Reduction of type V collagen using a dominant-negative strategy alters the regulation of fibrillogenesis and results in the loss of corneal- specific fibril morphology},
  author={Jeffrey K. Marchant and Rita A Hahn and Thomas F. Linsenmayer and David E. Birk},
  journal={The Journal of Cell Biology},
  year={1996},
  volume={135},
  pages={1415 - 1426}
}
A number of factors have been implicated in the regulation of tissue-specific collagen fibril diameter. Previous data suggest that assembly of heterotypic fibrils composed of two different fibrillar collagens represents a general mechanism regulating fibril diameter. Specifically, we hypothesize that type V collagen is required for the assembly of the small diameter fibrils observed in the cornea. To test this, we used a dominant-negative retroviral strategy to decrease the levels of type V… CONTINUE READING

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A fibrillar collagen gene , COLllA 1 , is essential for skeletal morphogene

  • T. F. Linsenmayer, M I. Hendrix, C. D. Little
  • 1995

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