Reduction of tumorigenesis and invasion of human breast cancer cells by whey acidic protein (WAP).

@article{Nukumi2007ReductionOT,
  title={Reduction of tumorigenesis and invasion of human breast cancer cells by whey acidic protein (WAP).},
  author={Naoko Nukumi and Tokuko Iwamori and Kiyoshi Kano and Kunihiko Naito and Hideaki Tojo},
  journal={Cancer letters},
  year={2007},
  volume={252 1},
  pages={65-74}
}
Whey acidic protein (WAP) is a major component of whey, which has two or three WAP motif domains characterized by a four-disulfide core (4-DSC) structure similar to the serine protease inhibitor. We have previously found that WAP inhibits the proliferation of mammary epithelial cells in vitro and in vivo [N. Nukumi, K. Ikeda, M. Osawa, T. Iwamori, K. Naito, H. Tojo, Regulatory function of whey acidic protein in the proliferation of mouse mammary epithelial cells in vivo and in vitro, Dev. Biol… CONTINUE READING
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