• Medicine
  • Published in Biochemical pharmacology 2002

Reduction of tumor necrosis factor-alpha (TNF-alpha) related nuclear factor-kappaB (NF-kappaB) translocation but not inhibitor kappa-B (Ikappa-B)-degradation by Rho protein inhibition in human endothelial cells.

@article{Hippenstiel2002ReductionOT,
  title={Reduction of tumor necrosis factor-alpha (TNF-alpha) related nuclear factor-kappaB (NF-kappaB) translocation but not inhibitor kappa-B (Ikappa-B)-degradation by Rho protein inhibition in human endothelial cells.},
  author={Stefan Hippenstiel and Bernd Schmeck and Joachim Seybold and Matthias Kruell and Christoph von Eichel-Streiber and Norbert Suttorp},
  journal={Biochemical pharmacology},
  year={2002},
  volume={64 5-6},
  pages={
          971-7
        }
}
Degradation of inhibitor kappa-B (Ikappa-B) followed by translocation of nuclear factor-kappaB (NF-kappaB) into the nucleus and activation of gene expression is essential in tumor necrosis factor-alpha (TNF-alpha)-signaling. In order to analyze the role of Rho proteins in TNF-alpha-induced NF-kappaB-activation in human umbilical cord vein endothelial cells (HUVEC) we used Clostridium difficile toxin B-10463 (TcdB-10463) which inactivates RhoA/Rac1/Cdc42 by glucosylation and Clostridium… CONTINUE READING

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