Reduction of toxic metabolite formation of acetaminophen.

  title={Reduction of toxic metabolite formation of acetaminophen.},
  author={Eszter Hazai and L{\'a}szl{\'o} Vereczkey and Katalin Monostory},
  journal={Biochemical and biophysical research communications},
  volume={291 4},
Acetaminophen is a widely used over-the-counter drug that causes severe hepatic damage upon overdose. Cytochrome P450-dependent oxidation of acetaminophen results in the formation of the toxic N-acetyl-p-benzoquinone-imine (NAPQI). Inhibition of cytochrome P450 enzymes responsible for NAPQI formation might be useful--besides N-acetylcysteine treatment--in managing acetaminophen overdose. Investigations were carried out using human liver microsomes to test whether selective inhibition of… CONTINUE READING


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