Reduction of the slow inward current of isolated rat ventricular cells by thiamylal and halothane.

@article{Ikemoto1985ReductionOT,
  title={Reduction of the slow inward current of isolated rat ventricular cells by thiamylal and halothane.},
  author={Y. Ikemoto and Atsuko Yatani and Hiroyuki Arimura and Jun-ichi Yoshitake},
  journal={Acta anaesthesiologica Scandinavica},
  year={1985},
  volume={29 6},
  pages={583-6}
}
The barbiturates and halothane exert a negative inotropic effect on the myocardium. A reduction in the slow inward current, carried mainly by calcium ions, is an important factor for the underlying mechanism because the calcium current during the action potential provides the calcium ions for accompanying contraction, supplies Ca ions to the sarcoplasmic reticulum for subsequent contractions, and induces Ca release from the store site. It has been suggested that reduction in the slow inward… CONTINUE READING

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