Reduction of the secretory response to Escherichia coli heat-stable enterotoxin by thiol and disulfide compounds.

Abstract

We examined the effects of disulfide and thiol compounds on Escherichia coli heat-stable enterotoxin (ST) and cyclic GMP-induced secretion. Both cystamine and cystine (disulfide compounds) reduced the secretory responses to submaximal doses of ST in suckling mice (at 0.5 mumol per mouse) and reduced ST activation of guanylate cyclase (by 33 to 73% at 1 mM… (More)

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@article{Greenberg1983ReductionOT, title={Reduction of the secretory response to Escherichia coli heat-stable enterotoxin by thiol and disulfide compounds.}, author={Robert Greenberg and J. A. Dunn and R. L. Guerrant}, journal={Infection and immunity}, year={1983}, volume={41 1}, pages={174-80} }