Reduction of the in vitro cytotoxic lymphocyte response produced by in vivo exposure to semiallogeneic cells: recruitment or active suppression?

@article{Miller1976ReductionOT,
  title={Reduction of the in vitro cytotoxic lymphocyte response produced by in vivo exposure to semiallogeneic cells: recruitment or active suppression?},
  author={Richard Gustav Miller and Rebecca A. Phillips},
  journal={Journal of immunology},
  year={1976},
  volume={117 5 Pt.2},
  pages={
          1913-21
        }
}
Twenty-four hours after intravenous injection of (C57BL/6 X DBA/2)F1 hygrid lymphoid cells into C57BL/6 mice, the in vitro cytotoxic lymphocyte (CL) response of the C57BL/6 spleen and LN cells against DBA/2 alloantigens can be greatly reduced. The reduction is specific for the foreign alloantigens injected; is reduced by irradiating the cells before injection; develops significantly within 10 min of injection, thereafter increasing with a time constant of about 2 hr; varies with the number and… CONTINUE READING