Reduction of sympathetic hyperactivity by enalapril in patients with chronic renal failure.

@article{Ligtenberg1999ReductionOS,
  title={Reduction of sympathetic hyperactivity by enalapril in patients with chronic renal failure.},
  author={Gerry Ligtenberg and Peter J Blankestijn and P. Liam Oey and Inge H. T. Klein and Lioe-Ting Dijkhorst-Oei and Frans Boomsma and George H. Wieneke and Alexander C. van Huffelen and Hein A. Koomans},
  journal={The New England journal of medicine},
  year={1999},
  volume={340 17},
  pages={1321-8}
}
BACKGROUND Inhibition of angiotensin-converting enzyme (ACE) reduces the risk of cardiovascular problems in patients with chronic renal failure. This effect may be due in part to a decrease in sympathetic nervous activity, but no direct evidence of such an action is available. METHODS We studied muscle sympathetic-nerve activity in 14 patients with hypertension, chronic renal failure, and increased plasma renin activity before, during, and after administration of the ACE inhibitor enalapril… CONTINUE READING
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We studied muscle sympathetic - nerve activity in 14 patients with hypertension , chronic renal failure , and increased plasma renin activity before , during , and after administration of the ACE inhibitor enalapril .
We studied muscle sympathetic - nerve activity in 14 patients with hypertension , chronic renal failure , and increased plasma renin activity before , during , and after administration of the ACE inhibitor enalapril .
Ten other patients with similar clinical characteristics were studied before and during treatment with the calcium - channel blocker amlodipine .
We studied muscle sympathetic - nerve activity in 14 patients with hypertension , chronic renal failure , and increased plasma renin activity before , during , and after administration of the ACE inhibitor enalapril .
We studied muscle sympathetic - nerve activity in 14 patients with hypertension , chronic renal failure , and increased plasma renin activity before , during , and after administration of the ACE inhibitor enalapril .
A single dose of the sympatholytic drug clonidine caused a greater fall in blood pressure in the patients than in the control subjects .
Ten other patients with similar clinical characteristics were studied before and during treatment with the calcium - channel blocker amlodipine .
Ten other patients with similar clinical characteristics were studied before and during treatment with the calcium - channel blocker amlodipine .
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